After Edward and Alphonse Elric's reckless disregard for alchemy's fundamental laws, the brothers scour a war-torn land for the Philosopher's Stone, a fabled relic which grants the ability to perform alchemy in impossible ways.

As young boys, Edward & Alphonse Elric once dabbled in the forbidden art of human alchemy to try to resurrect their dead mother. As a result, Ed lost one arm and one leg, while Al lost his entire body and had his spirit sealed inside a suit of armor. Now, both boys are searching for the fabled Philosopher's Stone to restore what they've lost.